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OCR: il the The three major factors that one are biosynthesis and release of al c hormone angiotensin II, adrenocortico ngiotensin II is (ACTH), and potassium. Of t at; various factors almost certainly the most im s to this can alter the adrenal respons hormone. See also: es . Biosynthesis of Steroid Ho ne Secretion · Circadian Variation of Ald See later: . Aldosterone Measurement